Featured Publications
Slivicki RA, Wang JG, Nhat VT, Kravitz AV, Creed MC, Gereau RW
bioRxiv. DOI: 10.1101/2023.12.04.569809
Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia
Bhuiyan S, Xu M, Yang L, Semizoglou E, Bhatia P, Pantaleo KI, Tochitsky I, Jain AA, Erdogan B, Blair S, Cat V, Mwirigi JM, Sankaranarayanan I, Tavares-Ferreira D, Green U, McIlvried LA, Copits BA, Bertels Z, Del Rosario JS, Widman A, Slivicki RA, Yi J, Woolf CJ, Lennerz JK, Whited J, Price TJ, Gereau RW, Renthal W.
bioRxiv. doi: 10.1101/2023.07.04.547740.
Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons
McIlvried LA, Del Rosario JS, Pullen MY, Wangzhou A, Sheahan TD, Shepherd AJ, Slivicki RA, Lemen JA, Price TJ, Copits BA, Gereau RW
bioRxiv. doi: https://doi.org/10.1101/2023.06.13.544829
Ibrahim KM, Massaly N, Yoon H-J, Sandoval R, Widman AJ, Heuermann RJ, Williams S, Post W, Pathiranage S, Lintz T, Zec A, Park A, Yu W, Kash TL, Gereau RW, and Moron JA.
Nature Communications. (2024) 15:750.
Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons
Yi J, Bertels Z, Del Rosario J, Widman AJ, Slivicki RA, Payne M, Susser HM, Copits BA, Gereau RW
Pain. (2024) 165(1):p 202-215. DOI: 10.1097/j.pain.0000000000003013
Cell type-specific dissection of sensory pathways involved in descending modulation
Nguyen E, Grajales-Reyes JG, Gereau RW, Ross SE
Trends in Neurosciences. (2023) 46:7, 539-550.
A TRPV4-dependent neuro-immune axis in the spinal cord promotes neuropathic pain
Hu X, Du L, Liu S, Lan Z, Zang K, Zhao Y, Yang X Xie Z, Wang PL, Chen L, Yi Z, Samineni VK, Wang Y, Lavine KJ, Gereau RW 4th, Wu GF, Hu HZ
Journal of Clinical Investigation. (2023) 26:3161507
Stuart T, Jeang W, Slivicki R, Brown B, Burton A, Brings V, Alcarcon-Segovia L, Agyare P, Ruiz Z, Tyree A, Pruitt L, Madhvapathy S, Niemiec M, Zhuang J, Krishnan S, Copits B, Rogers J, Gereau RW, Samineni V, Bandodkar A, Gutruf P.
ACS Nano. (2023) 17(1):561-574.
Oral oxycodone self-administration leads to features of opioid misuse in male and female mice
Slivicki R, Earnest T, Chang YH, Pareta R, Casey E, Li JN, Tooley J, Abiraman K, Vachez YM, Wolf D, Sackey J, Pitchai D, Moore T, Gereau RW 4th, Copits BA, Kravitz AV, Creed MC.
Addiction Biology. (2023) 28 (1):e13253. doi:10.1111/adb.13253
Laser stimulation of the skin for quantitative study of decision-making and motivation
Pai J, Ogasawara T, Bromberg-Martin ES, Ogasawara K, Gereau RW, Monosov IE
Cell Reports Methods. (2022) 2(9)100296
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
Taveres-Ferreira D, Shiers S, Ray PR, Wangzhou A, Jeevakuma V, Sankaranarayanan I, Cervantes AM, Reese JC, Chamessian A, Copits BA, Dougherty PM, Gereau RW, Burton MD, Dussor G, Price TJ.
Science Translational Medicine. (2022) 14, eabj8186.
Brings VE, Payne MA, Gereau 4th RW.
Pain Reports. (2022) Volume 7 – Issue 5 – p e1035
Slivicki R, Yi JW, Brings V, Huynh P, Gereau RW 4th.
Pain. (2022) 163(8):1603-1621. doi: 10.1097/j.pain.0000000000002550
Avraham O, Chamessian A, Feng R, Yang L, Halevi AE, Moore AM, Gereau 4th RW, Cavalli V.
Pain (2022) 163(12):2348-2364. doi: 10.1097/j.pain.0000000000002628
Cellular, circuit, and transcriptional framework for modulation of itch in the central amygdala.
Samineni VK, Grajales-Reyes JG, Grajales-Reyes GE, Tycksen E, Copits BA, Pedersen C, Ankudey ES, Sackey JN, Sewell SB, Bruchas MR, Gereau RW 4th.
eLife. (2021) 10:e68130 DOI: 10.7554/eLife.68130
A photoswitchable GPCR-based opsin for synaptic terminal inhibition.
Copits BA, O’Neill PO, Gowrishankar R, Yoo JJ, Meshik X, Parker KE, Spangler SM, Vasquez AM, Staner MC, Vogt SK, Samineni VK, Gautam N, Sunahara RK, Gereau RW 4th, Bruchas MR.
Neuron. (2021) doi: https://doi.org/10.1016/j.neuron.2021.04.026
Grajales-Reyes JG, Copits BA, Lie F, Yu Y, Avila R, Vogt SK, Huang Y, Banks AR, Rogers JA, Gereau RW 4th*, Golden JP*
Nature Protocols. (2021). DOI: https://doi.org/10.1038/s41596-021-00532-2
IL-33 Signaling in Sensory Neurons Promotes Dry Skin Itch
Trier AM, Mack MR, tamari M, Ver Heul AM, Avraham O, Fredman A, Guo J, Dehner C, Oetjen LK, Zhao Y, Feng J, Kubo M, Gereau RW, Coble D, Cavalli V, Davidson S, Hu H, Liu Q, Kim BS.
Journal of Allergy and Clinical Immunology. (2021) Sept 21; doi: 10.1016/j.jaci.2021.09.014.
Wireless multilateral devices for optogenetic studies of individual and social behaviors
Yuan Y, Wu M, Vazquez-Guardado A, Wegener AJ, Grajales-Reyes JG, Deng Y, Wang T, Avila R, Moreno JA, Minkowicz S, Dumronprechachan V, Lee J, Zhang S, Legaria AA, Ma Y, Mehta S, Franklin D, Hartman L, Bai W, Han M, Zhao H, Lu W, Yu Y, Sheng X, Banks A, Yu X, Donaldson ZR, Gereau RW 4th, Good CH, Xie Z, Huang Y, Kozorovitskiy Y, Rogers, JA.
Nature Neuroscience. (2021). Jul;24(7):1035-1045.
Renthal W, Chamessian A, Curatolo M, Davidson S, Burton M, Dib-Hajj S, Dougherty PM, Ebert A, Gereau RW 4th, Ghetti A, Gold MS, Hoben G, Menichella DM, Mercier P, Ray WZ, Salvemini D, Seal RP, Waxman S, Woolf CJ, Stucky CL, Price TJ.
Neuron. (2021) 9:1426-29.
Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding.
Luskin A, Bhatti DL, Mulvey B, Pedersen CE, Girven KS, Oden-Brunson H, Kimbell K, Blackburn T, Sawyer A, Gereau RW 4th, Dougherty JD, Bruchas MR.
Science Advances. 2021. 7(9) eabd3666.
Wangzhou A, McIlvried LA, Paige C, Barragan-Iglesias P, Shiers S, Ahmad A, Guzman CA, Dussor G, Ray PR, Gereau RW 4th, Price TJ.
Pain. 2020 161(7):1497-1517.
Cavallone LC, Doshi T, Montana MC, Valtcheva M, Morgan CD, Wages JM, Frey K, Kharasch ED and Gereau RW
Pain. 2020. 161(1):135-146.
Rengarajan S, Knoop KA, Rengarajan A, Chai, JN, Grajales-Reyes JG, Samineni VK, Russler-Germain EV, Ranganathan P, Fasano A, Sayuk G, Gereau RW, Kau AL, Knights D, Kashyap PC, Ciorba MA, Newberry RD, Hsiey C-S
Cell Reports Medicine. 2020. 1(7):100124.
Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray.
Samineni VK, Grajales-Reyes JG, Sundaram SS, Yoo JJ and Gereau RW
Nature Communications. 10:4356
A Wireless Closed Loop System for Optogenetic Peripheral Neuromodulation
Mickle, A.D., Won SM, Noh KN, Yoon J, Meacham KW, Xue Y, McIlvried LA, Copits BA, Samineni VK, Crawford KE, Kim DH, Srivastava P, Kim BH, Min S, Shiuan Y, Yun Y, Payne MA, Zhang J, Jang H, Li Y, Lai HH, Huang Y, Park SI, Gereau RW, Rogers JA.
Nature. 2019. 565(7739):361-365
Zhang Y, Mickle AD, Gutruf P, McIlvried L, Guo H, Wu Y, Golden JP, Xue Y, Grajales-Reyes JG, Wang X, Krishnan S, Xie Y, Peng D, Su C, Zhang F, Reeder JT, Vogt SK, Huang Y, Rogers JA, and Gereau RW
Science Advances. 2019. 5 Eaaw5296.
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward
Kyle E. Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR
Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.06.034
Myelinating Schwann cells ensheath multiple axons in the absence of Fbxw7.
Harty B, Coelho F, Peease-Raissi S, Mogha A, Ackerman S, Herbert A, Gereau RW, Golden JG, Lyons D, Chan J, and Monk K
Nature Communications. 2019. 10(1)2976.
Wireless, Battery-Free Optoelectronic Systems as Subdermal Implants for Local Tissue Oximetry.
Zhang H, Gutruf P, Meacham K, Montana MC, Zhao X, Chiarelli AM, Vázquez-Guardado A, Norris A, Lu L, Guo Q, Xu C, Wu Y, Zhao H, Ning X, Bai W, Kandela I, Haney CR, Chanda D, Gereau RW, Rogers JA
Science Advances. 2019. 5 eaaw0873
Massaly N, Copits BA, Wilson-Poe A, Hipolito L, Markovic T, Yoon HJ, Liu S, Walicki MC, Bhatti DL, Sirohi S, Klass A, Walker BM, Neve R, Cahill C, Shoghi K, Gereau RW, McCall JG, Al-Hasani R, Bruchas MR, Moron JA
Neuron. 2019. 102, 1-10. doi.org/10.1016/j.neuron.2019.02.029
A bright future? Optogenetics in the periphery for pain research and therapy.
Mickle AD, Gereau RW 4th.
Pain. 2018 Sep;159 Suppl 1:S65-S73.
Natural wax for transient electronics.
Won SM, Koo J, Crawford KE, Mickle AD, Xue Y, Min S, McIlvried LA, Yan Y, Lee SM, MacEwan MR, Huang YG, Gereau RW, and Rogers JA (2018)
Advanced Functional Materials. 28(32). 1801819.
Macrophage angiotensin II type 2 receptor triggers neuropathic pain.
Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW 4th, Mohapatra DP.
Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8057-E8066
Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.
Shepherd AJ, Copits BA, Mickle AD, Karlsson P, Kadunganattil S, Haroutounian S, Tadinada SM, de Kloet AD, Valtcheva MV, McIlvried LA, Sheahan TD, Jain S, Ray PR, Usachev YM, Dussor G, Krause EG, Price TJ, Gereau RW 4th, Mohapatra DP.
Journal of Neuroscience. 2018 Aug 8;38(32):7032-7057.
Parathyroid hormone-related peptide activates and modulates TRPV1 channel in human DRG neurons.
Shepherd AJ, Mickle AD, McIlvried LA, Gereau RW 4th, Mohapatra DP.
European Journal of Pain. 2018 Oct;22(9):1685-1690
Optogenetic Induction of Colonic Motility in Mice.
Hibberd TJ, Feng J, Luo J, Yang P, Samineni VK, Gereau RW 4th, Kelley N, Hu H, Spencer NJ.
Gastroenterology. 2018 Aug;155(2):514-528.e6.
Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat.
Carlin D, Golden JP, Mogha A, Samineni VK, Monk KR, Gereau RW 4th, Cavalli V.
eNeuro. 2018 May 3;5(2). pii: ENEURO.0436-17.2018.
Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons.
Sheahan TD, Valtcheva MV, McIlvried LA, Pullen MY, Baranger DAA, Gereau RW 4th.
eNeuro. 2018 Apr 13;5(2). pii: ENEURO.0412-17.2018.
Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.
Noh KN, Park SI, Qazi R, Zou Z, Mickle AD, Grajales-Reyes JG, Jang KI, Gereau RW 4th, Xiao J, Rogers JA, Jeong JW.
Small. 2018 Jan;14(4).
Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain.
Samineni VK, Mickle AD, Yoon J, Grajales-Reyes JG, Pullen MY, Crawford KE, Noh KN, Gereau GB, Vogt SK, Lai HH, Rogers JA, Gereau RW 4th.
Scientific Reports. 2017 Nov 20;7(1):15865
Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain.
Sheahan TD, Siuda ER, Bruchas MR, Shepherd AJ, Mohapatra DP, Gereau RW 4th, Golden JP.
Neurobiology of Pain. 2017 Aug-Dec;2:1-12
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.
Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS.
Cell. 2017 Sep 21;171(1):217-228.e13
Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics.
Samineni VK, Yoon J, Crawford KE, Jeong YR, McKenzie KC, Shin G, Xie Z, Sundaram SS, Li Y, Yang MY, Kim J, Wu D, Xue Y, Feng X, Huang Y, Mickle AD, Banks A, Ha JS, Golden JP, Rogers JA, Gereau RW 4th.
Pain. 2017 Nov;158(11):2108-2116.
Anti-vascular endothelial growth factor treatment decreases bladder pain in cyclophosphamide cystitis: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network animal model study.
Lai HH, Shen B, Vijairania P, Zhang X, Vogt SK, Gereau RW 4th.
BJU Int. 2017 Oct;120(4):576-583
Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray.
Samineni VK, Grajales-Reyes JG, Copits BA, O’Brien DE, Trigg SL, Gomez AM, Bruchas MR, Gereau RW 4th.
eNeuro. 2017 Mar 29;4(2
Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study.
Lai HH, Jemielita T, Sutcliffe S, Bradley CS, Naliboff B, Williams DA, Gereau RW 4th, Kreder K, Clemens JQ, Rodriguez LV, Krieger JN, Farrar JT, Robinson N, Landis JR; MAPP Research Network.
Journal of Urology. 2017 Sep;198(3):622-631.
Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics.
Shin G, Gomez AM, Al-Hasani R, Jeong YR, Kim J, Xie Z, Banks A, Lee SM, Han SY, Yoo CJ, Lee JL, Lee SH, Kurniawan J, Tureb J, Guo Z, Yoon J, Park SI, Bang SY, Nam Y, Walicki MC, Samineni VK, Mickle AD, Lee K, Heo SY, McCall JG, Pan T, Wang L, Feng X, Kim TI, Kim JK, Li Y, Huang Y, Gereau RW 4th, Ha JS, Bruchas MR, Rogers JA.
Neuron. 2017 Feb 8;93(3):509-521.e3
Postinflammatory hyperpigmentation after human cold pain testing.
Wolz MJ, Sadler KE, Long CC, Brenner DS, Kim BS, Gereau RW 4th, Kolber BJ.
Pain Reports. 2016 Aug;1(2).
Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics.
Park SI, Shin G, McCall JG, Al-Hasani R, Norris A, Xia L, Brenner DS, Noh KN, Bang SY, Bhatti DL, Jang KI, Kang SK, Mickle AD, Dussor G, Price TJ, Gereau RW 4th, Bruchas MR, Rogers JA.
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8169-E8177.
Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits.
Copits BA, Pullen MY, Gereau RW 4th.
Pain. 2016 Nov;157(11):2424-2433. Review.
Symptom Variability and Early Symptom Regression in the MAPP Study: A Prospective Study of Urological Chronic Pelvic Pain Syndrome.
Stephens-Shields AJ, Clemens JQ, Jemielita T, Farrar J, Sutcliffe S, Hou X, Landis JR; MAPP Research Network.
Journal of Urology. 2016 Nov;196(5):1450-1455
Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.
Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW4th.
Nature Protocols. 2016 Oct;11(10):1877-88
Group II mGluRs suppress hyperexcitability in mouse and human nociceptors.
Davidson S, Golden JP, Copits BA, Ray PR, Vogt SK, Valtcheva MV, Schmidt RE, Ghetti A, Price TJ, Gereau RW 4th.
Pain. 2016 Sep;157(9):2081-8
Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.
Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jang KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huang Y, Montana MC, Golden JP, Bruchas MR, Gereau RW 4th, Rogers JA.
Nature Biotechnology. 2015 Dec;33(12):1280-1286.
Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States.
Sheahan TD, Copits BA, Golden JP, Gereau RW 4th.
PLoS One. 2015 Jul 21;10(7):e0133191
ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival.
O’Brien DE, Alter BJ, Satomoto M, Morgan CD, Davidson S, Vogt SK, Norman ME, Gereau GB, Demaro JA 3rd, Landreth GE, Golden JP, Gereau RW 4th.
Journal of Neuroscience. 2015 Jun 24;35(25):9491-507
Lai H, Gereau RW 4th, Luo Y, O’Donnell M, Rudick CN, Pontari M, Mullins C, Klumpp DJ.
Urology. 2015 Jun;85(6):1454-65
Spatiotemporal control of opioid signaling and behavior.
Siuda ER, Copits BA, Schmidt MJ, Baird MA, Al-Hasani R, Planer WJ, Funderburk SC, McCall JG, Gereau RW 4th, Bruchas MR.
Neuron. 2015 May 20;86(4):923-935.
A simple and inexpensive method for determining cold sensitivity and adaptation in mice.
Brenner DS, Golden JP, Vogt SK, Gereau RW 4th.
Journal of Visualized Experiments. 2015 Mar 17;(97)
Valtcheva MV, Samineni VK, Golden JP, Gereau RW 4th, Davidson S.
Journal of Pain. 2015 Apr;16(4):346-56.
Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors.
Valtcheva MV, Davidson S, Zhao C, Leitges M, Gereau RW 4th.
Molecular Pain. 2015 Jan 6;11:1
Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study.
Krieger JN, Stephens AJ, Landis JR, Clemens JQ, Kreder K, Lai HH, Afari N, Rodríguez L, Schaeffer A, Mackey S, Andriole GL, Williams DA; MAPP Research Network.
Journal of Urology. 2015 Apr;193(4):1254-62.
A pain research agenda for the 21st century.
Gereau RW 4th, Sluka KA, Maixner W, Savage SR, Price TJ, Murinson BB, Sullivan MD, Fillingim RB.
Journal of Pain. 2014 Dec;15(12):1203-14.
Zammataro M, Sortino MA, Parenti C, Gereau RW 4th, Chiechio S.
Molecular Pain. 2014 Nov 18;10:68
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.
Chen Y, Kanju P, Fang Q, Lee SH, Parekh PK, Lee W, Moore C, Brenner D, Gereau RW 4th, Wang F, Liedtke W.
Pain. 2014 Dec;155(12):2662-72.
A technique to measure cold adaptation in freely behaving mice.
Brenner DS, Vogt SK, Gereau RW 4th.
Journal of Neuroscince Methods. 2014 Oct 30;236:86-91
Brenner DS, Golden JP, Vogt SK, Dhaka A, Story GM, Gereau RW IV.
Pain. 2014 Oct;155(10):2124-33
The MAPP research network: design, patient characterization and operations.
Landis JR, Williams DA, Lucia MS, Clauw DJ, Naliboff BD, Robinson NA, van Bokhoven A, Sutcliffe S, Schaeffer AJ, Rodriguez LV, Mayer EA, Lai HH, Krieger JN, Kreder KJ, Afari N, Andriole GL, Bradley CS, Griffith JW, Klumpp DJ, Hong BA, Lutgendorf SK, Buchwald D, Yang CC, Mackey S, Pontari MA, Hanno P, Kusek JW, Mullins C, Clemens JQ; MAPP Research Network Study Group.
BMC Urol. 2014 Aug 1;14:58.
The MAPP research network: a novel study of urologic chronic pelvic pain syndromes.
Clemens JQ, Mullins C, Kusek JW, Kirkali Z, Mayer EA, Rodríguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Buchwald D, Andriole GL, Lucia MS, Landis JR, Clauw DJ; MAPP Research Network Study Group.
BMC Urol. 2014 Aug 1;14:57.
Human sensory neurons: Membrane properties and sensitization by inflammatory mediators.
Davidson S, Copits BA, Zhang J, Page G, Ghetti A, Gereau RW.
Pain. 2014 Sep;155(9):1861-1870.
Lai HH, Vetter J, Jain S, Gereau RW 4th, Andriole GL.
Journal of Urology. 2014 Dec;192(6):1679-85.
Lai HH, Gardner V, Ness TJ, Gereau RW 4th.
Journal of Urology. 2014 May;191(5):1294-9.